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Regulation of Apical Membrane Traffic

Polarized epithelial cells have the remarkable capacity to generate and maintain differentiated apical and basolateral plasma membrane domains with distinct protein and lipid compositions. This is a... (more)

Regulation of Polarized Biosynthetic Traffic by Phosphatidylinositol Metabolizing Enzymes

The local generation of distinct phosphatidylinositol (PI) lipid species has been implicated in the regulation of numerous membrane trafficking events and in the control of cytoskeletal dynamics... (more)

Mechanism of Glycan-Dependent Sorting in Polarized Epithelial Cells

Newly synthesized lysosomal membrane proteins reach their destination via a combination of direct routing and indirect transport via the plasma membrane. We are examining the trafficking... (more)

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