Polarized epithelial cells have the remarkable capacity to generate and maintain differentiated apical and basolateral plasma membrane domains with distinct protein and lipid compositions. This is a... (more)
The local generation of distinct phosphatidylinositol (PI) lipid species has been implicated in the regulation of numerous membrane trafficking events and in the control of cytoskeletal dynamics... (more)
Newly synthesized lysosomal membrane proteins reach their destination via a combination of direct routing and indirect transport via the plasma membrane. We are examining the trafficking... (more)
The epithelial sodium channel (ENaC) is made up of three homologous subunits (a,b, and g). Although the channel can assemble in multiple combinations, the fully active form is thought... (more)
