« back to projects

Mechanism of Glycan-Dependent Sorting in Polarized Epithelial Cells


Both N- and O-linked glycans have been implicated as apical targeting signals. We seek to understand how these posttranslational modifications are recognized and enable segregation of selected membrane and secretory proteins into apically-destined vesicles. We have found that apical sorting of the sialomucin endolyn is dependent on terminal processing of two of the eight N-glycans on the protein. We are currently working to dissect the molecular mechanism(s) that directs polarized sorting of endolyn along both the biosynthetic and postendocytic pathways.  

Epithelial Sodium Channel»
Apical Membrane Traffic »
Phosphatidylinositol Metabolizing Enzymes »

Interdisciplinary Biomedical Training Program »

Renal Electrolyte division »
Program in Integrative Molecular Biology (PIMB) »
Cell Biology and
Molecular Physiology
Training Program »
Molecular Virology
and Microbiology
Training Program »
Office of Academic
Career Development »
About Pittsburgh »
Lab Projects »
Lab Members »
Publications »
Contact Dr. Weisz »
© 2004 Weisz Laboratory. All Rights Reserved